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M94A3016.TXT
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1994-10-25
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Document 3016
DOCN M94A3016
TI Serum hyaluronan in HIV and in AIDS related Kaposi's sarcoma.
DT 9412
AU Blum L; Guechot J; Picard O; Cabane J; Giboudeau J; Imbert JC; Intern
Med Dept, St Antoine Hosp, Paris, France.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):172 (abstract no. PB0113). Unique
Identifier : AIDSLINE ICA10/94369559
AB OBJECTIVES: Hyaluronan (hyaluronic acid, HA) is synthesized by
mesenchymal cells, activated by growth factors and cytokines (EGF, PDGF,
TGF beta, IGF-1, IL1). Kaposi's sarcoma (KS) is a tumor of mesenchymal
origin, and data suggest that the induction of the lesions involves a
pathway of events mediated by cytokines. We tested the hypothesis that
HA synthesis might be activated and serum HA levels increased in HIV
patients, particulary in those with associated KS. METHODS: We measured
serum HA levels in normal subjects (n = 40), in asymptomatic (n = 61),
in symptomatic HIV patients (n = 12), in patients with AIDS related KS
(n = 11). In two patients with KS receiving a chemotherapy, serum HA was
determined monthly for 6 months. RESULTS: We found no significant
difference in serum HA in asymptomatic HIV patients (39 +/- 26
micrograms/l) when compared with normal subjects (32 +/- 29
micrograms/l). Serum HA was significantly increased in patients with
AIDS related KS (317 +/- 299 micrograms/l) and in symptomatic HIV
patients (215 +/- 127 micrograms/l), p < 0,01. In one patient with
cutaneous KS which received chemotherapy serum HA decreased from 542
micrograms/l before treatment to 181 and 215 micrograms/l, (at 2 and 4
months) when there was clinical improvement. Later, as the KS
progressed, HA increased to 658 micrograms/l at 6 months. In the other
patient with visceral KS serum HA increased (137 to > 1000 micrograms/l)
as the tumour progressed according to the CT scan. CONCLUSIONS: Serum HA
levels are increased in symptomatic HIV patients, particularly in those
with associated KS. HA might be a useful tool to monitor the treatment
of KS.
DE Acquired Immunodeficiency Syndrome/*BLOOD Follow-Up Studies Human
Hyaluronic Acid/*BLOOD HIV Infections/*BLOOD Sarcoma,
Kaposi's/*BLOOD/DRUG THERAPY Skin Neoplasms/*BLOOD/DRUG THERAPY
Treatment Outcome Tumor Markers, Biological/*BLOOD MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).